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Conversely, we observed a clear reduction during the drug potency when the PEGylation of DOTAP/cholesterol liposomes was elevated from 5 mol% to 10 mol%. This is likely a result of the lowered mobile uptake of your liposomes, as PEGylation can impede the binding of cationic liposomes With all the cytoplasm membrane [18]. To optimize the PEGylation